Molecular and developmental analysis of non-coding RNA metabolism in" C. elegans" : the exoribonuclease XRN2 and the RNA- binding proteins SART-3 and USIP-1
- Rüegger, Stefan
DOIAbstract
About three quarters of a eukaryotic genome are transcribed into RNA. However, only <2% of these transcripts are translated into protein while the bulk of transcripts execute their biological function as RNA. Non-protein coding RNAs (ncRNAs) associate with proteins in ribonucleoprotein particles (RNPs) to regulate gene expression at various stages thereby greatly increasing the functional complexity of the genome. Nonetheless, the function and mode of action of the vast majority of ncRNAs is unknown and even in well studied examples little is known about the post-transcriptional regulation of ncRNAs themselves. In the thesis at hand, I explored the molecular and developmental functions of proteins implicated in the metabolism of ncRNAs, nam...
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